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PEMF : Inhibition of tumor cell or tissue proliferation
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Abstract
Cancer is one of the major diseases that endanger human health. Current treatment options have low patient tolerance, poor prognosis, and strong side effects. Pulsed electromagnetic therapy can selectively kill cancer cells by taking advantage of their own electromagnetic sensitivity specificity. Pulsed electric fields (PEFs), pulsed electromagnetic fields (PEMFs), and cold atmospheric plasma (CAP) are three main means that have promising application in cancer therapy. Pulsed electromagnetic therapy showed significant anticancer ability in vitro and in vivo. In this paper, we summarize the basic principles, methods, and state of art research of PEFs, PEMFs, and PEMFs for cancer therapy. Based on cancer pro-oxidation therapy, we propose a combination therapy of electromagnetic field-enhanced CAP for cancer therapy.
Inhibition of tumor cell or tissue proliferation
Zeng et al. found that tumor growth in mice was inhibited by the effect of 0.6–2.0 T magnetic field. The metabolism, mitosis, and high-speed anomalous growth of tumor cells were inhibited in the irradiated group. de Seze et al. applied a magnetic field with an intensity of 0.12 T and a frequency of 0.8 Hz to natural killer cells and observed a significant increase in the proliferation of natural killer cells within 1 week compared to the previous one, indicating that a magnetic field of this intensity can improve the body's ability to suppress cancer. Tuffet and de Seze found that 0.18 T, 0.8 Hz unipolar square wave pulsed magnetic field reduced the proliferation of isolated cervical cancer cells by 15%. Under the same parameters, pulsed magnetic field treatment for 8 h a day, 5 days a week, significantly prolonged the survival of tumor-bearing mice. The effect of the nonuniform field was better than that of the uniform field, with the pulsed magnetic field producing the highest induced current at the edge of the subject and the lowest induced current at the center. Cameron et al. used a pulsed magnetic field (15 mT, 120 pulses/s) to treat human breast cancer cells (MDA-MB-231) transplanted into mice. It was found that the growth of breast cancer was effectively inhibited in the irradiated mice compared to the nonmagnetic field irradiated mice, while the tumors in the original lung metastases in the mice were significantly reduced, with slow tumor growth and no significant harmful side effects. Filipovic et al. investigated the effects of a 50 Hz magnetic field on different types of cancer cells. Breast cancer cells MDA-MB-231, colorectal cancer cells SW-480, and HCT-116 were irradiated under a specific magnetic field for 24–72 h, and the results showed that the growth of all three types of cancer cells was significantly inhibited. Williams et al.61 further found that 10 min of daily 10, 15 or 20 mT pulsed magnetic field irradiation (120 pulses/s) significantly slowed tumor growth and reduced vascularization relative to mice not exposed to magnetic fields.
(Source : OnlineLibrayWiley)
